Alessandra Chesi

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2

  Nature Communications · 2026-01-12 · 3 citations

• Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains

  Molecular Cell · 2026-01-01 · 5 citations

• Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer’s disease risk

  npj Dementia · 2025-12-16

• 3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility

  Genome biology · 2025-12-08 · 1 citations

• The gSOS polygenic score is associated with bone density and fracture risk in childhood

  Journal of Bone and Mineral Research · 2025-10-14 · 2 citations

• GWAS-informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density

  Genome biology · 2025-10-03

• Cross-species variant-to-function analyses implicate <i>MEIS1</i> in conferring sleep abnormalities and impaired cerebellar developmentPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-08-06 · 2 citations

• Polygenic prediction of body mass index and obesity through the life course and across ancestries

  Nature Medicine · 2025-07-21 · 31 citations

• Integrated genomic analysis and CRISPRi implicates <i>EGFR</i> in Alzheimer’s disease riskPreprint

  medRxiv · 2025-06-26 · 1 citations

• Mapping chromatin interactions at melanoma susceptibility loci uncovers distant cis-regulatory gene targets

  The American Journal of Human Genetics · 2025-05-22 · 7 citations

• Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry

  UNC Libraries · 2025-05-13

• The gSOS Polygenic Score is Associated with Bone Density and Fracture Risk in ChildhoodPreprint

  medRxiv · 2025-04-23

• Integration of Alzheimer’s GWAS, 3D genomics, and single-cell CRISPRi non-coding screen implicates causal variants in a microglial enhancer regulating <i>TSPAN14</i>Preprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-04-01 · 2 citations

• Author response: 3D genomic features across &gt;50 diverse cell types reveal insights into the genomic architecture of childhood obesity

  2025-01-15

• 3D genomic features across &gt;50 diverse cell types reveal insights into the genomic architecture of childhood obesity

  eLife · 2025-01-15 · 3 citations

• Variant‐to‐function mapping of late‐onset Alzheimer’s disease GWAS loci in human microglial models implicates <i>RTFDC1</i> as an effector gene at the <i>CASS4</i> locus

  Alzheimer s & Dementia · 2024-12-01 · 1 citations

• Variant‐gene pair in <i>silico</i> analyses and functional validation of LOAD GWAS loci in human brain‐relevant cell types identify <i>EGFR</i> as a target gene for potential drug repurposing

  Alzheimer s & Dementia · 2024-12-01

• Author response: 3D genomic features across &gt;50 diverse cell types reveal insights into the genomic architecture of childhood obesity

  2024-11-27

• 3D genomic features across &gt;50 diverse cell types reveal insights into the genomic architecture of childhood obesityPreprint

  eLife · 2024-11-27

• Mapping chromatin interactions at melanoma susceptibility loci and cell-type specific dataset integration uncovers distant gene targets of <i>cis</i> -regulationPreprint

  medRxiv · 2024-11-15 · 1 citations