Alex Zhavoronkov

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• Target identification and assessment in the era of AI

  Nature Reviews Drug Discovery · 2026-04-20 · 5 citations

• Abstract 4561: Cbl-b inhibition with ISM3830 restores innate and adaptive immunity and demonstrates antitumor activity against solid tumors <i>in vitro</i> and <i>in vivo</i>

  Cancer Research · 2026-04-03

• Cover Feature: An Internal Sulfur–Lone Pair Interaction Enabled the Discovery of Potent and Sub‐Family Selective PKMYT1 Inhibitors (ChemMedChem 6/2026)

  ChemMedChem · 2026-03-27

• An Internal Sulfur–Lone Pair Interaction Enabled the Discovery of Potent and Sub‐Family Selective PKMYT1 Inhibitors

  ChemMedChem · 2026-03-26 · 1 citations

• Polyploid cardiomyocytes define disease-specific transcriptional states in the mammalian heart

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-02-03 · 3 citations

• Delphi-derived Framework for Healthspan-Oriented Care: The Cardiometabolic Health PerspectivePreprint

  SSRN Electronic Journal · 2026-01-01

• Recent advance in macrocyclic CDK inhibitors

  Future Medicinal Chemistry · 2025-12-09 · 1 citations

• Design, Synthesis and Biological Evaluation of Novel, Potent, Selective and Orally Available DGKα Inhibitors for the Treatment of Tumors

  Journal of Medicinal Chemistry · 2025-12-01 · 1 citations

• Discovery of a bifunctional PKMYT1-targeting PROTAC empowered by AI-generation

  Nature Communications · 2025-11-28 · 14 citations

• Discovery and Biological Evaluation of Novel, Potent, and Orally Available CBLB Inhibitors

  Journal of Medicinal Chemistry · 2025-11-12 · 1 citations

• Evaluation of (Z)-endoxifen as a potential therapy for glioblastoma multiforme through computational and experimental analyses

  Scientific Reports · 2025-10-31

• The Right to Be Remembered: Preserving Maximally Truthful Digital Memory in the Age of AIPreprint

  ArXiv.org · 2025-10-17

• Modelling sex differences of neurological disorders in vitro

  Nature Reviews Bioengineering · 2025-10-13 · 3 citations

• GENESIS-IPF: PHASE 2A COHORT CHARACTERISTICS AND LUNG IMAGING INDICATE CORRELATES OF RESPONSE TO ISM001-055 (RENTOSERTIB) IN PATIENTS WITH IDIOPATHIC PULMONARY FIBROSIS

  CHEST Journal · 2025-10-01

• Rentosertib, a generative AI-discovered TNIK inhibitor improves lung function in IPF patients

  2025-09-27

• Comparison of the baseline clinical and HRCT characteristics of Insilico’s ISM001_055 phase 2a trial cohort in China with real-world IPF datasets

  2025-09-27

• <scp>AlphaFold</scp> Kinase Optimizer: Enhancing Virtual Screening Performance Through Automated Refinement of <scp>AlphaFold</scp> ‐Based Kinase Structures

  Proteins Structure Function and Bioinformatics · 2025-09-16 · 1 citations

• Discovery of Novel, Potent, Selective, and Orally Available DGKα Inhibitors for the Treatment of Tumors

  Journal of Medicinal Chemistry · 2025-09-08 · 1 citations

• Bridging Physics and Aging Biology: Insights from the First Physics in Aging Biology Workshop

  2025-09-01

• A novel, covalent and highly synthetically accessible SARS-CoV-2 Mpro chloroacetamide inhibitor

  2025-08-26