Alison Goate

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• Combining post-mortem and neuroimaging measures of brain amyloidosis to accelerate genomic discovery

  Brain · 2026-06-23

• Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease

  Neurology · 2026-04-08

• Retraction notice to “Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying the PSEN1 H163R mutation” [Stem Cell Res. 79 (2024) 103495]

  Stem Cell Research · 2026-03-19

• Uncovering NMDA receptor-mediated high firing activity in excitatory human neurons

  iScience · 2026-02-17

• Reduced expression of mitochondrial lactamases in myeloid cells might be protective for AD

  Alzheimer s & Dementia · 2025-12-01

• Alternative Anastrozole Target CYP4V2 Impairs Neurons in Preclinical Models of Inherited TauopathyPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-11-29

• Lymphoid gene expression supports neuroprotective microglia function

  Nature · 2025-11-05 · 16 citations

• The curious case of a heterozygous loss-of-function PSEN1 variant associated with early-onset Alzheimer’s disease

  Molecular Neurodegeneration Advances · 2025-10-20

• Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder

  Nature Communications · 2025-10-13 · 6 citations

• Evaluating the causal effect of mitochondrial dysfunction on Alzheimer’s and Parkinson’s disease using Polygenic Risk Scores and Mendelian RandomizationPreprint

  medRxiv · 2025-09-27 · 1 citations

• APOE4 promotes cerebrovascular fibrosis and amyloid deposition via a pericyte-to-myofibroblast transitionPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-09-09 · 1 citations

• The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology

  Alzheimer s & Dementia · 2025-09-01 · 3 citations

• The Curious Case of a Heterozygous Loss-of-Function PSEN1 variant associated with Early-Onset Alzheimer’s DiseasePreprint

  Research Square · 2025-08-27

• Differential associations of APOE and TREM2 variants with glial fibrillary acidic protein and neurofilament light in plasma of UK Biobank participants support distinct disease mechanisms

  Molecular Psychiatry · 2025-07-15 · 2 citations

• A rapid and robust protocol for generating loss-of-function alleles in pluripotent stem cells

  STAR Protocols · 2025-07-04

• Cytokine-induced reprogramming of human macrophages toward Alzheimer’s disease-relevant molecular and cellular phenotypes in vitro

  Cell Reports · 2025-06-25 · 3 citations

• The Relationship between Alcohol Use Disorder, Measures of Cognitive Decline, and Alzheimer Disease Biomarkers in Older AdultsPreprint

  medRxiv · 2025-05-31

• Human iPSC-RPE with the PSEN1H163R pathogenic variant recapitulates Alzheimer’s disease features and reveals melanosome defectsPreprint

  Research Square · 2025-05-12

• Childhood Trauma and <i>APOEε4</i> are Associated with Adolescent Brain Function, Posttraumatic Stress, and Alcohol-related OutcomesPreprint

  medRxiv · 2025-05-06

• High-throughput measurements of neuronal activity in single human iPSC-derived glutamate neuronsPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-04-07