Benjamin Izar

Columbia University Irving Medical Center

Full Professor(heuristic)

Cancer Immunotherapy and Biomarkers · Oncology

h-index48

i10-index78

Publications284

Citations19,077

Grants

28 total · 12 active

NIH #1R01CA312637-01

Restoring anti-tumor immunity in chromosomally unstable tumors

Active

Amount: $NaNK
Period: 2026-06-02 → 2031-05-31
PIs: 1
Est. capacity / PI: ~ students

Awarded at COLUMBIA UNIVERSITY HEALTH SCIENCES

NIH #1R01AI199896-01

Systematic variant-to-pathway, phenotype, and precision treatment response evaluation in genetic disorders of the immune system (GDIS)

Active

Amount: $NaNK
Period: 2026-05-01 → 2031-04-30
PIs: 2
Est. capacity / PI: ~ students

Awarded at COLUMBIA UNIVERSITY HEALTH SCIENCES

NIH #5U54CA274506-03

Single-Cell, Spatial and Functional Dissection of Cancer Cell States, Co-Evolving Ecosystems, and Vulnerabilities During Tumor Progression and Metastasis

Active

Amount: $NaNK
Period: 2023-09-19 → 2028-08-31
PIs: 1
Est. capacity / PI: ~ students

Awarded at COLUMBIA UNIVERSITY HEALTH SCIENCES

Student capacity is a rough estimate from remaining award size, split equally among PIs. Actual funding decisions vary.

Lab Funding Health

Find elsewhere

Institution / lab homepage Search on ResearchGate

In-Field Influence

0.0020

PageRank within Oncology co-authorship network

Explore collaboration map

Admission Signals

New NIH award: Restoring anti-tumor immunity in chromosomally unstable tumors2026-06-02
New paper: Targeting of MEK and Autophagy in Pancreatic Adenocarcinoma and Analysis of Treatment Sensitivity in Preclinical and Clinical Models: MEKiAUTO (JCO Precision Oncology)2026-06-01
New NIH award: Systematic variant-to-pathway, phenotype, and precision treatment response evaluation in genetic disorders of the immune system (GDIS)2026-05-01
New preprint: Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS–chemokine–myeloid axis2025-05-10
New NIH award: Single-Cell, Spatial and Functional Dissection of Cancer Cell States, Co-Evolving Ecosystems, and Vulnerabilities During Tumor Progression and Metastasis2023-09-19
New NIH award: Single-Cell, Spatial and Functional Dissection of Cancer Cell States, Co-Evolving Ecosystems, and Vulnerabilities During Tumor Progression and Metastasis2023-09-19
New NIH award: Single-Cell, Spatial and Functional Dissection of Cancer Cell States, Co-Evolving Ecosystems, and Vulnerabilities During Tumor Progression and Metastasis2023-09-19
New NIH award: Multi-cellular interactions defining the human brain metastatic niche2023-05-01
New NIH award: Multi-cellular interactions defining the human brain metastatic niche2023-05-01
New NIH award: Multi-cellular interactions defining the human brain metastatic niche2023-05-01

Data Freshness

Publications as of 2026-07-01
Grants as of 2026-06-30

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ORCID: 0000-0003-2379-6702

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

Potential Collaborators

Recent Publications

Last 2 years · showing 20 of 45

Targeting of MEK and Autophagy in Pancreatic Adenocarcinoma and Analysis of Treatment Sensitivity in Preclinical and Clinical Models: MEKiAUTO
JCO Precision Oncology · 2026-06-01
Targeting CD73-A <sub>2a</sub> R-Mediated Adenosine Signaling at the Tumor-Immune Interface Overcomes Radioresistance
bioRxiv (Cold Spring Harbor Laboratory) · 2026-05-29
Mapping human natural killer cell development in tonsil
bioRxiv (Cold Spring Harbor Laboratory) · 2026-05-14
Abstract 4961: Cell type-specific adipokine signaling networks in the breast tumor microenvironment uncovered by high-plex spatial imaging
Cancer Research · 2026-04-03
Integrative Genomic, Transcriptomic, and Microbiome Profiles of Colon Cancer by Ancestry Provide Insights into Molecular Distinctions
medRxiv · 2026-03-28
PKMYT1 inhibition induces DNA damage and synergizes with immune checkpoint blockade in <i>CCNE1</i> -amplified gastroesophageal adenocarcinoma
bioRxiv (Cold Spring Harbor Laboratory) · 2025-12-19
Massively scalable generation, discovery, and clinical (re-)classification of inborn errors of immunity using cutting-edge genome engineering 4011
The Journal of Immunology · 2025-11-01
1345 Initial phase 1a/1b results of STK-012, an α/β IL-2 receptor biased partial agonist, with pembrolizumab, pemetrexed, and carboplatin in 1L PD-L1 negative non-squamous NSCLC
2025-11-01
Cellular states associated with metastatic organotropism and survival in patients with pancreatic ductal adenocarcinoma
Nature Genetics · 2025-10-27 · 9 citations
Concurrent local therapy extends clinical benefit of tebentafusp in metastatic uveal melanoma patients
The Oncologist · 2025-09-29 · 6 citations
Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis
Nature · 2025-09-10 · 49 citations
Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment
Cell · 2025-06-20 · 12 citations
CheMo4METPANC: Combination chemotherapy (gemcitabine and nab-paclitaxel), chemokine (C-X-C) motif receptor 4 inhibitor (motixafortide), and immune checkpoint blockade (cemiplimab) in metastatic treatment-naïve pancreatic adenocarcinoma—Updated clinical and translational findings.
Journal of Clinical Oncology · 2025-05-28 · 3 citations
Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS–chemokine–myeloid axisPreprint
bioRxiv (Cold Spring Harbor Laboratory) · 2025-05-10 · 2 citations
Central Nervous System Metastases from Primary Lung Carcinoma: Significance of RNA Fusion Testing and Early Versus Late Metastases
Journal of Personalized Medicine · 2025-05-01
Massively Scalable Generation, Discovery, and Clinical (Re)Classification of Inborn Errors of Immunity Using Cutting-Edge Genome Engineering
Journal of Human Immunity · 2025-04-25
Abstract 4699: Intratumoral adenosine: Contributions from host versus tumor and interaction with radiotherapy
Cancer Research · 2025-04-21
The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasisPreprint
bioRxiv (Cold Spring Harbor Laboratory) · 2025-03-19 · 1 citations
A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients
Genome biology · 2025-03-14 · 7 citations
Hepatic stellate cells control liver zonation, size and functions via R-spondin 3
Nature · 2025-03-12 · 82 citations

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Benjamin Izar

Grants

Restoring anti-tumor immunity in chromosomally unstable tumors

Systematic variant-to-pathway, phenotype, and precision treatment response evaluation in genetic disorders of the immune system (GDIS)

Single-Cell, Spatial and Functional Dissection of Cancer Cell States, Co-Evolving Ecosystems, and Vulnerabilities During Tumor Progression and Metastasis

All Grants

Restoring anti-tumor immunity in chromosomally unstable tumors

Systematic variant-to-pathway, phenotype, and precision treatment response evaluation in genetic disorders of the immune system (GDIS)

Single-Cell, Spatial and Functional Dissection of Cancer Cell States, Co-Evolving Ecosystems, and Vulnerabilities During Tumor Progression and Metastasis

Single-Cell, Spatial and Functional Dissection of Cancer Cell States, Co-Evolving Ecosystems, and Vulnerabilities During Tumor Progression and Metastasis

Single-Cell, Spatial and Functional Dissection of Cancer Cell States, Co-Evolving Ecosystems, and Vulnerabilities During Tumor Progression and Metastasis

Multi-cellular interactions defining the human brain metastatic niche

Multi-cellular interactions defining the human brain metastatic niche

Multi-cellular interactions defining the human brain metastatic niche

Multi-cellular interactions defining the human brain metastatic niche

Mechanisms of liver metastasis and associated resistance to immunotherapy

The role of the CD58:CD2 axis in cancer immune evasion and resistance to immunotherapy

The role of the CD58:CD2 axis in cancer immune evasion and resistance to immunotherapy

Mechanisms of liver metastasis and associated resistance to immunotherapy

Mechanisms of liver metastasis and associated resistance to immunotherapy

Mechanisms of liver metastasis and associated resistance to immunotherapy

Mechanisms of liver metastasis and associated resistance to immunotherapy

Mechanisms of liver metastasis and associated resistance to immunotherapy

Mechanisms of liver metastasis and associated resistance to immunotherapy

The role of the CD58:CD2 axis in cancer immune evasion and resistance to immunotherapy

Mechanisms of liver metastasis and associated resistance to immunotherapy

Dissecting drug resistance in serial uveal melanoma biopsies using integrated, multi-modal single-cell profiling and novel machine learning tools.

Dissecting drug resistance in serial uveal melanoma biopsies using integrated, multi-modal single-cell profiling and novel machine learning tools.

Dissecting mechanisms of immunotherapy resistance in melanoma patients

Dissecting mechanisms of immunotherapy resistance in melanoma patients

Dissecting mechanisms of immunotherapy resistance in melanoma patients

Dissecting mechanisms of immunotherapy resistance in melanoma patients

Dissecting mechanisms of immunotherapy resistance in melanoma patients

Dissecting mechanisms of immunotherapy resistance in melanoma patients

Career Trajectory

Research Cluster Map

Potential Collaborators

Recent Publications