Brian D. Strahl

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• A submission checklist to improve transparency and replicability of functional genomics data analyses

  UNC Libraries · 2026-06-13

• Discovery of Small-Molecule Antagonists of PHF1 and 19 Demonstrates the Ligandability of PRC2 Accessory Proteins.

  UNC Libraries · 2026-06-09

• Multivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage

  UNC Libraries · 2026-06-02

• Tandem bromodomains of BRD4 cooperatively read poly-acetylated nucleosomes to enhance chromatin engagement and regulate breast cancer phenotypes

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-04-24

• Casein Kinase II Phosphorylation of Spt6 Enforces Transcriptional Fidelity by Maintaining Spn1-Spt6 Interaction

  UNC Libraries · 2026-04-14

• Rapid CRISPR–Cas9 Genome Editing in S. cerevisiae

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-03-30 · 1 citations

• Chromatin stability safeguards mitochondrial homeostasis and prevents mTORC1 hyperactivation

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-12-12

• HMGN1 and HMGN2 are recruited to acetylated and histone variant H2A.Z-containing nucleosomes to regulate chromatin state and transcription

  Journal of Biological Chemistry · 2025-11-29

• A needed nomenclature for nucleosomes

  Molecular Cell · 2025-10-01 · 10 citations

• Multivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage

  Nature Communications · 2025-09-29 · 7 citations

• Author response: SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model, and its catalytic activity is regulated by histone acetylation

  2025-09-15

• SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model, and its catalytic activity is regulated by histone acetylation

  eLife · 2025-09-15 · 2 citations

• Author response: SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model and its catalytic activity is regulated by histone acetylation

  2025-08-29

• SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model and its catalytic activity is regulated by histone acetylation

  eLife · 2025-08-29

• A SETD2–CDK1–lamin axis maintains nuclear morphology and genome stability

  Nature Cell Biology · 2025-08-01 · 10 citations

• The histone methyltransferase SETD2 regulates HIV expression and latency

  UNC Libraries · 2025-07-25

• SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model, and its catalytic activity is regulated by histone acetylation

  eLife · 2025-07-09

• Author response: SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model and its catalytic activity is regulated by histone acetylation

  2025-07-09

• SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model and its catalytic activity is regulated by histone acetylationPreprint

  eLife · 2025-07-09

• Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response

  Nucleic Acids Research · 2025-07-08 · 1 citations