Christina S. Leslie

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• <i>SPP1</i> ^hi macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium

  Science Translational Medicine · 2026-06-24

• Author Correction: Ontogeny and transcriptional regulation of Thetis cells

  Nature · 2026-06-16

• Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells

  The Journal of Experimental Medicine · 2026-05-29

• <i>SPP1</i> ^hi macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-05-03

• SPEN loss drives extra-follicular diffuse large B cell lymphoma with female-specific lethality and therapeutic vulnerabilities

  Cancer Discovery · 2026-04-21

• Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion

  Nature Genetics · 2026-04-01 · 2 citations

• A Genetically Engineered Human Organoid Model Reveals Distinct Genetic and Epigenetic Barriers of Lineage Plasticity in Early PDAC Transformation

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-03-11

• Opposing functions of distinct regulatory T cell subsets in colorectal cancer

  Immunity · 2025-12-15 · 3 citations

• The Histone Methyltransferase KMT2D Is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration-Resistant Prostate Cancer

  Cancer Research · 2025-12-11

• Signaling induced biophysical disruption of repressed chromatin domains drives immune cell fate

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-12-11

• Supplementary Data from Microenvironment-Driven Dynamic Chromatin Changes in Glioblastoma Recapitulate Early Neural Development at Single-Cell Resolution

  2025-11-24

• Supplementary Figures from Microenvironment-Driven Dynamic Chromatin Changes in Glioblastoma Recapitulate Early Neural Development at Single-Cell Resolution

  2025-11-24

• FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicityPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-11-14

• Arginine methylation on MSI2 drives resistance to PRMT1/5 inhibitors in lymphoma, controls translation and dictates cell fate

  Blood · 2025-11-03

• Rheumatoid arthritis synovial fibroblasts modulate T cell activation

  JCI Insight · 2025-10-07 · 4 citations

• Predicting the regulatory genome

  Nature Reviews Genetics · 2025-09-16 · 3 citations

• ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L

  Nature Genetics · 2025-08-26 · 12 citations

• Kitlo hematopoietic stem cells exhibit distinct lymphoid-primed chromatin landscapes that enhance thymic reconstitution

  Nature Communications · 2025-07-04 · 5 citations

• Disruption of TAD hierarchy promotes LTR co-option in cancer

  Nature Genetics · 2025-06-30 · 5 citations

• Discovery of NANOG enhancers and their essential roles in self-renewal and differentiation in human embryonic stem cells

  Stem Cell Reports · 2025-05-29 · 4 citations