David E. Root

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity

  Nature Communications · 2026-04-08

• Protein language model-based fitness estimates facilitate resistance mutation identification

  ChemRxiv · 2026-03-15

• TYK2 mediates neuroinflammation in Alzheimer’s disease brains with TDP-43 pathology

  Nature Communications · 2026-03-14

• Abstract PR006: Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity

  Cancer Research · 2026-03-05

• Aurora kinase A is a synthetic lethal target in FANCA-deficient cancers

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-02-06

• Abstract B026: O-mannosylation and protein maturation checkpoints represent therapeutic opportunities in BRAF fusion protein oncogenesis

  Cancer Research · 2026-01-13

• Supplementary Figure S2 from Hyper-Dependence on NHEJ Enables Synergy between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma

  2025-12-17

• Supplementary Figure S4 from Hyper-Dependence on NHEJ Enables Synergy between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma

  2025-12-17

• Supplementary Figure S11 from Hyper-Dependence on NHEJ Enables Synergy between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma

  2025-12-17

• Supplementary Figures and Tables from A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas

  2025-12-11

• Khsrp depletion selectively eliminates AML cells that persist after venetoclax/azacitidine therapy via modulating SLC23A1-transported TET enzyme cofactors

  Blood · 2025-11-03

• Abstract B024: Uncovering replication stress vulnerabilities in pediatric low grade gliomas using a genome wide CRISPR-Cas9 knockout screen

  Cancer Research · 2025-09-25

• Abstract A032: Molecular insights into KIAA1549::BRAF fusion proteins: Implications for targeted therapy in pediatric low-grade gliomas

  Cancer Research · 2025-09-25

• Abstract B016: Factors Driving Chemo-persistence in Atypical Teratoid Rhabdoid Tumors

  Cancer Research · 2025-09-25

• Abstract B019: O-mannosylation represents a therapeutic opportunity in BRAF fusion protein oncogenesis

  Cancer Research · 2025-09-25

• Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and CuproptosisPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-09-12

• Supplementary Table S9 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets

  2025-09-04

• Supplementary Table S4 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets

  2025-09-04

• Supplementary Table S10 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets

  2025-09-04

• Supplementary Table S8 from Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets

  2025-09-04