Don W. Cleveland

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• Mutant SOD1 expressed by oligodendrocytes aggregates in myelinic nanochannels and accelerates disease progression in familial ALS mice

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-06-11

• An emergent disease-associated motor neuron state precedes cell death in ALS

  Cell · 2026-06-01

• HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells

  UNC Libraries · 2026-04-08

• Statins and genetic inhibition of the mevalonate pathway activate an ATF3-STMN2 regenerative program

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-02-24 · 1 citations

• Multimodal spatial transcriptomics determines repeat expansion, huntingtin aggregation, and selective cortical neuron loss in Huntington’s Disease

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-12-27

• Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes

  Science · 2025-12-11 · 7 citations

• Dual-targeting snRNA gene therapy rescues STMN2 and UNC13A splicing in TDP-43 proteinopathies

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-12-03

• TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins

  Nature Cell Biology · 2025-10-31 · 3 citations

• Author Correction: A two-step mechanism for epigenetic specification of centromere identity and function

  Nature Cell Biology · 2025-06-23

• Stathmin-2 enhances motor axon regeneration after injury independent of its binding to tubulin

  Proceedings of the National Academy of Sciences · 2025-05-20 · 14 citations

• Aberrant splicing in Huntington’s disease accompanies disrupted TDP-43 activity and altered m6A RNA modification

  Nature Neuroscience · 2025-01-06 · 38 citations

• CK1δ/ε-mediated TDP-43 phosphorylation contributes to early motor neuron disease toxicity in amyotrophic lateral sclerosis

  Acta Neuropathologica Communications · 2024-12-04 · 7 citations

• CK1δ/e-mediated TDP-43 phosphorylation contributes to early motor neuron disease toxicity in amyotrophic lateral sclerosisPreprint

  Research Square · 2024-11-08 · 1 citations

• Acetylation of lysine 82 initiates TDP-43 nuclear loss of function by disrupting its nuclear importPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2024-09-07 · 9 citations