Donald M. O’Rourke

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• Topical resiquimod elicits systemic protection and improves anti-PD1 therapy in melanoma via priming of CD8+ T cells

  Cancer Immunology Research · 2026-06-11

• The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM

  Cell · 2026-06-01

• Abstract LB138: Natural killer cell-based signaling in EGFR-targeted KIR-CAR T overcomes CD3-based CAR T functional deficits to eliminate resistant glioblastomas in vivo

  Cancer Research · 2026-04-17

• Abstract 3444: Spatial profiling of recurrent glioblastoma in a Phase I clinical trial reveals favorable immune remodeling induced by intracerebroventricular CAR T therapy

  Cancer Research · 2026-04-03

• Metabolic Imaging and Molecular Signatures Reveal Metabolic Phenotypes in Recurrent Glioblastoma

  Journal of Nuclear Medicine · 2026-03-19

• The development of CAR T cells for patients with CNS malignancies

  Nature Reviews Clinical Oncology · 2025-12-01 · 3 citations

• TMOD-20. Growth rates of patient-derived tumor organoids reflect glioblastoma patients’ heterogeneity in survival

  Neuro-Oncology · 2025-11-01

• IMG-33. Unveiling glioblastoma heterogeneity with deep learning derived MRI subtyping: insights from the global ReSPOND consortium

  Neuro-Oncology · 2025-11-01

• CNSC-24. A CHOLINERGIC NEURON-TO-TUMOR CIRCUIT ENHANCES HUMAN GLIOBLASTOMA PROGRESSION VIA SYNAPTIC AND PARACRINE MECHANISMS

  Neuro-Oncology · 2025-11-01

• DDDR-63. Immune remodeling in CSF and tumor predicts response to CAR T therapy in glioblastoma

  Neuro-Oncology · 2025-11-01

• IMG-66. Self-supervised multimodal learning for survival prediction in glioblastoma: a multicenter study from the ReSPOND consortium

  Neuro-Oncology · 2025-11-01

• EPCO-36. DENOISING POSTMORTEM SINGLE-NUCLEI DATA REVEALS GLIOBLASTOMA-ADJACENT INFLAMMATORY OLIGODENDROCYTES SUGGESTIVE OF AN INJURY-LIKE RESPONSE

  Neuro-Oncology · 2025-11-01

• Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma

  Science Advances · 2025-10-15 · 1 citations

• Survival and CNS Disease Control among Patients with HER2 Low vs. HER2 High Metastatic Breast Cancer with Brain Metastases Treated with SRS

  International Journal of Radiation Oncology*Biology*Physics · 2025-09-01

• Clinical and Dosimetric Predictors of Severe Radiation-Induced Lymphopenia in Patients with Newly Diagnosed IDH-Wildtype High Grade Glioma Undergoing Adjuvant Radiotherapy

  International Journal of Radiation Oncology*Biology*Physics · 2025-09-01

• A Real-World Analysis of Clinical Prognostic Factors Influencing Survival in Patients with High-Grade Glioma (HGG) Receiving Radiotherapy (RT)

  International Journal of Radiation Oncology*Biology*Physics · 2025-09-01

• Next-Generation Sequencing of Intraoperatively Acquired Cerebrospinal Fluid and Matched Tumor Tissue in Patients Undergoing Surgical Resection for Glioblastoma

  JCO Precision Oncology · 2025-09-01 · 1 citations

• Checkpoint antibody receptor modified ARMed CAR T circumvents the suppressive immunome in GBM

  Frontiers in Immunology · 2025-07-31 · 2 citations

• Intratumoral preservation of the stem-like malignant cell proportion in glioblastoma, prognostic impact, and its radiomethylomic signatures

  Neuro-Oncology · 2025-07-28 · 1 citations

• Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma

  UNC Libraries · 2025-07-25