Frederick P. Roth

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles. Billmann et al.

  Mendeley Data · 2026-06-18

• Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles. Billmann et al.

  Mendeley Data · 2026-06-18

• Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles

  Cell · 2026-04-27 · 1 citations

• Experimental assessment of AI-based interactome mapping

  Nature Communications · 2026-04-04

• Dynamic engagement of dual-role regulators by the Sin3 complex

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-02-26 · 1 citations

• Clinical validation of large-scale functional assays: CanVIG-UK recommendations for truthset assembly based on 2122 gene-truthset-assay evaluations

  Open MIND · 2026-02-23

• Clinical validation of large-scale functional assays: CanVIG-UK recommendations for truthset assembly based on 2122 gene-truthset-assay evaluations

  Zenodo (CERN European Organization for Nuclear Research) · 2026-02-23 · 1 citations

• A scalable approach to resolving variants of uncertain significance

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-02-15 · 3 citations

• A global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles. Billmann et al.

  Mendeley Data · 2026-01-01

• Mapping the Functional Landscape of KCNQ1 to Define Ion Channel Mechanisms and Arrhythmia Risk

  medRxiv · 2025-12-16

• Systematic and proactive evaluation of AIRE missense variant effectsPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-11-18

• The functional landscape of coding variation in the familial hypercholesterolemia gene <i>LDLR</i>

  Science · 2025-10-30 · 21 citations

• Landscapes of missense variant impact for human superoxide dismutase 1

  The American Journal of Human Genetics · 2025-09-16 · 5 citations

• BOGO: A Proteome-Wide Gene Overexpression Platform for Discovering Rational Cancer Combination TherapiesPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-09-07 · 1 citations

• Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine

  Nature Reviews Cardiology · 2025-09-01 · 5 citations

• Comprehensively Testing the Function of Missense Variation in the <i>STK11</i> Tumour SuppressorPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-07-18

• Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effectsPreprint

  Cell · 2025-07-05 · 3 citations

• A global genetic interaction map of a human cell reveals conserved principles of genetic networksPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-07-02 · 5 citations

• Scaled multidimensional assays of variant effect identify sequence-function relationships in hypertrophic cardiomyopathyPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-05-27 · 2 citations

• Guidelines for releasing a variant effect predictor

  Genome biology · 2025-04-15 · 25 citations