Gregory A. Petsko

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• RhoGEF12 regulates endosomal SORL1-retromer and its inhibition is therapeutic in human neuronal models of Alzheimer’s disease

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-03-09

• How biochemists became flexible in their views on the ability of structural techniques to illuminate the dynamics of proteins

  Structural Dynamics · 2025-03-01

• An Introduction to SORL1‐retromer Structure/Function and Its Role in Alzheimer’s Disease

  Alzheimer s & Dementia · 2024-12-01

• Validation of a binding site on the SORLA‐retromer complex that augments endosomal recycling: Implications for a novel class of AD drugs

  Alzheimer s & Dementia · 2024-12-01

• The <i>SORL1</i> p.Y1816C variant causes impaired endosomal dimerization and autosomal dominant Alzheimer’s disease

  Proceedings of the National Academy of Sciences · 2024-09-03 · 22 citations

• RIOK2 transcriptionally regulates TRiC and dyskerin complexes to prevent telomere shortening

  Nature Communications · 2024-08-20 · 9 citations