Gregory L. Challis

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• Substrate Scope and Catalytic Mechanism of α,β-Epoxyketone Synthase EpnF Illuminated by In Situ Esterase-Mediated Deprotection

  ACS Catalysis · 2026-06-25

• Cryptic starter amidation in antibiotic biosynthesis by <i>trans</i> -acyltransferase polyketide synthases

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-04-24

• Substrate scope and catalytic mechanism of α, β-epoxyketone synthase EpnF illuminated by <i>in situ</i> esterase-mediated deprotection

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-12-25

• Discovery of Late Intermediates in Methylenomycin Biosynthesis Active against Drug-Resistant Gram-Positive Bacterial Pathogens

  Journal of the American Chemical Society · 2025-10-27 · 3 citations

• Bioinformatics-based stereochemical elucidation of MM 46115: an unusual antiviral spirotetronate that inhibits clathrin-mediated endocytosisPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-09-18

• Phosphine-Mediated (3 + 2) Cycloaddition of Electron-Poor Terminal Alkynes: A Concise Route to Premethylenomycin C Lactone

  The Journal of Organic Chemistry · 2025-07-29 · 4 citations

• Biosynthesis of Biphenomycin-like Macrocyclic Peptides by Formation and Cross-Linking of <i>Ortho</i>-Tyrosines

  Journal of the American Chemical Society · 2025-06-26 · 18 citations

• Genome mining based on transcriptional regulatory networks uncovers a novel locus involved in desferrioxamine biosynthesis

  PLoS Biology · 2025-06-12 · 11 citations

• Discovery and Metabolic Origin of 4,4′-Dihydroxy-3,3′,5,5′-Tetrachlorobenzophenone from a <i>Burkholderia oklahomensis</i> Clinical IsolatePreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-05-18

• Discovery of late intermediates in methylenomycin biosynthesis active against drug-resistant Gram-positive bacterial pathogensPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-05-15 · 1 citations

• An <i>O</i> -acetylated derivative of piericidin A1 produced by <i>Kitasatospora</i> sp. A2-31 has potent activity against the cacao mirid bug, <i>Helopeltis bakeri</i> PoppiusPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-05-14

• Phosphine mediated (3 + 2) cycloaddition of electron-poor terminal alkynes: a concise route to pre-methylenomycin C lactone.Preprint

  ChemRxiv · 2025-05-08 · 1 citations

• Teicoplanin Nonribosomal Peptide Synthetase Is Unable to Incorporate Alpha-Ketoacid Building Blocks

  Biochemistry · 2025-04-11

• Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesisPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-03-14

• Nitrogen deletion in HDAC-targeting anticancer drug biosynthesisPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-03-14

• PARAS: High-Accuracy Machine Learning of Substrate Specificities in Nonribosomal Peptide SynthetasesPreprint

  JACS Au · 2025-01-10 · 27 citations

• Mode of Action and Mechanisms of Resistance to the Unusual Polyglycosylated Thiopeptide Antibiotic Persiathiacin A

  ACS Infectious Diseases · 2024-12-09 · 2 citations

• Molecular Basis for Short-Chain Thioester Hydrolysis by Acyl Hydrolases in <i>trans</i>-Acyltransferase Polyketide Synthases

  JACS Au · 2024-11-18 · 8 citations

• Gladiolin produced by pathogenic <i>Burkholderia</i> synergizes with amphotericin B through membrane lipid rearrangements

  mBio · 2024-10-18 · 4 citations

• Discovery and Biosynthesis of Persiathiacins: Unusual Polyglycosylated Thiopeptides Active Against Multidrug Resistant Tuberculosis

  ACS Infectious Diseases · 2024-08-27 · 5 citations