James Douglas Engel

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• LSD1 inhibition ameliorates congenital dyserythropoietic anemia type II

  Science Translational Medicine · 2026-03-25

• Lipid metabolism transcriptomic signature of defective erythropoiesis in Diamond Blackfan anemia syndrome

  Blood Advances · 2026-01-23

• Enhanced induction of fetal hemoglobin by the combination of decitabine with RN-1 in β-thalassemia/HbE erythroid progenitor cells

  Molecular Medicine · 2026-01-20

• p27Kip1 regulates γ-globin production

  Blood · 2025-12-18 · 2 citations

• Genome-wide analysis of pseudogenes reveals HBBP1’s human-specific essentiality in erythropoiesis and implication in β-thalassemia

  Developmental Cell · 2025-06-01

• A lipid metabolism defect is an underlying contributor to Diamond Blackfan anemia syndromePreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-05-27 · 1 citations

• Novel, potent, and orally bioavailable LSD1 inhibitors induce fetal hemoglobin synthesis in a sickle cell disease mouse model

  Blood · 2025-05-07 · 5 citations

• A genome-wide screen identifies genes required for erythroid differentiation

  Nature Communications · 2025-04-12 · 10 citations

• Disruption of the Malate-Aspartate Shuttle Leads to Anemia

  Blood · 2024-11-05

• The LSD1 Inhibitor RN1 Rescues Congenital Dyserythropoietic Anemia Type II

  Blood · 2024-11-05

• TR4 and BCL11A repress γ-globin transcription via independent mechanisms

  Blood · 2024-10-11 · 3 citations