John M. Denu

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• dCas9-metabolic enzyme fusions modulate global and locus-specific gene expression

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-05-10

• Methionine, Not <i>S</i> -adenosylmethionine, Acts as a Primary Metabolic Stress Signal for Chromatin Remodeling

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-05-05

• PD27-04 EPIGENETIC BIOMARKERS PREDICT RESPONSE TO ANDROGEN DEPRIVATION AND IDENTIFY NOVEL THERAPEUTIC TARGETS IN PROSTATE CANCER

  The Journal of Urology · 2026-04-27

• IP49-25 HISTONE-MODIFYING ENZYMES IN ANDROGEN-DEPRIVED PROSTATE CANCER: EZH1 AS A SYNERGISTIC THERAPEUTIC TARGET

  The Journal of Urology · 2026-04-27

• Abstract 5715: Histone-modifying enzymes in androgen-deprived prostate cancer: EZH1 as a synergistic therapeutic target

  Cancer Research · 2026-04-03

• Genetic loss of CHD1 regulates distinct histone post-translational modifications in the development of castration-resistant prostate cancer

  Neoplasia · 2026-02-19

• Abstract PR034: NSD2 inhibition in hormone sensitive prostate cancer synergizes with androgen deprivation therapy to improve tumor response

  Cancer Research · 2026-01-20

• Histone-modifying enzymes as drivers and therapeutic targets in androgen-resistant prostate cancer

  Frontiers in Endocrinology · 2026-01-12 · 1 citations

• Depletion of individual dietary amino acids induce distinct metabolic and chromatin states

  Journal of Biological Chemistry · 2025-12-17 · 2 citations

• A needed nomenclature for nucleosomes

  Molecular Cell · 2025-10-01 · 10 citations

• Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease

  Nature Communications · 2025-08-04 · 10 citations

• Gut microbiota–derived metabolite trimethylamine N-oxide alters the host epigenome through inhibition of S-adenosylhomocysteine hydrolase

  Journal of Biological Chemistry · 2025-07-25 · 8 citations

• H2A.Z deposition by the SWR complex is stimulated by polyadenine DNA sequences in nucleosomes

  PLoS Biology · 2025-05-12 · 2 citations

• Abstract 2277 Gut microbiota-derived metabolite Trimethylamine N-oxide alters the host epigenome through inhibition of S-adenosylhomocysteine hydrolase

  Journal of Biological Chemistry · 2025-05-01

• Abstract 2426 Metabolism-Driven Epigenetic Reprogramming: Dissecting the Role of Methionine and SAM in Histone Methylation and Heterochromatin Stability

  Journal of Biological Chemistry · 2025-05-01

• Abstract 2443 Fluctuations in central metabolite availability regulate global and site-specific chromatin mechanisms

  Journal of Biological Chemistry · 2025-05-01

• The role of <scp>ATP</scp> citrate lyase in myelin formation and maintenance

  Glia · 2024-09-25 · 5 citations

• Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s diseasePreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2024-09-24 · 2 citations