Lars M. Steinmetz

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• Multimodal phenotyping defines variant-to-function maps for RBM20 in dilated cardiomyopathy

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-06-11

• Harnessing lipid-driven immunometabolic pathways in omental metastases to enhance immunotherapy in patients with ovarian cancer

  Signal Transduction and Targeted Therapy · 2026-03-04 · 1 citations

• Sarcomeric remodelling in human heart failure unraveled by single molecule long read sequencing

  EMBO Molecular Medicine · 2026-01-13 · 3 citations

• Improved cloning-free one-step CRISPR-Cas12a-assisted tagging of mammalian genes using PCR generated reagents (PCR tagging)

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-12-02

• The editable landscape of the yeast genome reveals hotspots of structural variant formation

  Science Advances · 2025-10-31

• Innate immune responses to <i>Plasmodium falciparum</i> disrupt the blood-brain barrierPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-10-20 · 1 citations

• Pervasive co-regulation of alternative splicing with transcription initiation and termination.Preprint

  Research Square · 2025-10-15

• Prime editing corrects the dilated cardiomyopathy causing RBM20-P633L-mutation in human cardiomyocytes

  Molecular Therapy — Nucleic Acids · 2025-10-07 · 5 citations

• An unbiased survey of distal element-gene regulatory interactions with direct-capture targeted Perturb-seqPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-09-17 · 4 citations

• Mutational Scanning by Multiplexed Genome Editing of the Essential Transcription Termination Factor Nrd1Preprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-09-10

• AAV9-Mediated TNPO3 Overexpression in the Heart Rescues RBM20 Cardiomyopathy in Mice

  Circulation · 2025-09-08 · 1 citations

• Enhancer-targeting CRISPR screens at coronary artery disease loci suggest shared mechanisms of disease riskPreprint

  medRxiv · 2025-09-02 · 4 citations

• Functional phenotyping of genomic variants using joint multiomic single-cell DNA–RNA sequencing

  Nature Methods · 2025-09-01 · 16 citations

• Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model

  Nature Communications · 2025-08-06 · 12 citations

• The contribution of <i>RBM20</i> truncating variants to human cardiomyopathyPreprint

  medRxiv · 2025-07-27 · 3 citations

• CAMK2D causes heart failure in RBM20 cardiomyopathyPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-05-25

• Clonal tracing with somatic epimutations reveals dynamics of blood ageing

  Nature · 2025-05-21 · 42 citations

• A CRISPR/Cas9-based enhancement of high-throughput single-cell transcriptomics

  Nature Communications · 2025-05-19 · 7 citations

• tRNA modifications tune m6A-dependent mRNA decay

  Cell · 2025-04-30 · 37 citations

• Mapping Enhancer–Gene Interactions with Direct-Capture Targeted Perturb-seq (DC-TAP-seq) v1Preprint

  2025-04-01 · 1 citations