Leszek J. Klimczak

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• Somatic mutation landscape revealed by non-invasive iPSC derivation from urine cells

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-04-14

• APOBEC3A is the predominant global editor of cytosines in human mRNAs and in single-strand RNA viruses

  G3 Genes Genomes Genetics · 2026-03-28 · 2 citations

• APOBEC3A is the predominant global editor of cytosines in human mRNAs and in single-strand RNA viruses

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-02-12

• Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation

  UNC Libraries · 2025-11-06

• Mutation signatures specific to DNA alkylating agents in yeast and cancers

  UNC Libraries · 2025-11-06

• Glycidamide-induced hypermutation in yeast single-stranded DNA reveals a ubiquitous clock-like mutational motif in humans

  UNC Libraries · 2025-11-05

• Motif-Centered Analyses Reveal Universal and Tissue-Specific Mutagenic Mechanisms Operating in the Human BodyPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-10-08 · 3 citations

• Discovery and performance of DNA methylation panels for cancer detection and classification in bloodPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-09-18

• Environmental carcinogens often exacerbate endogenous mutagenic processes to enhance tumor promotion

  Cell Reports · 2025-07-01 · 3 citations

• APOBEC affects tumor evolution and age at onset of lung cancer in smokers

  Nature Communications · 2025-05-21 · 8 citations

• Hypomorphic mutation in the large subunit of replication protein A affects mutagenesis by human APOBEC cytidine deaminases in yeast

  G3 Genes Genomes Genetics · 2024-08-16 · 6 citations