Manolis Kellis

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• Regulatory landscape of widespread stop codon readthrough in <i>Drosophila</i>

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-06-12

• Dissecting Alzheimer’s disease heterogeneity by cross-trait polygenic prediction

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-05-15

• Expansion Revealing of Pathology Resolves Nanostructures Associated with Inflammatory Phenotypes in COVID-19 Decedent Human Brain Tissue

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-05-15

• Epigenetically constrained astrocyte states underlie prefrontal cortex vulnerability in Down syndrome–associated Alzheimer’s disease

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-04-21

• Role of AI in drug development: Current status, challenges, opportunities, and future promise

  Artificial Intelligence in Health · 2026-03-13

• Convergent Signals Encode Persistent Memory of Resilient States

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-12-17 · 1 citations

• Epigenetic control of metabolic identity across cell types

  BMC Genomics · 2025-12-10 · 2 citations

• Energy Conservation Drives Adaptive Specialization Through Fine-tuned Organizations

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-12-10 · 1 citations

• Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease

  Nature Aging · 2025-11-20 · 2 citations

• sc4D: spatio-temporal single-cell transcriptomics analysis through embedded optimal transport identifies joint glial response to Alzheimer’s disease pathologyPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-11-19

• Multi-omics analysis of a pig-to-human decedent kidney xenotransplant

  Nature · 2025-11-13 · 18 citations

• PRISM: ancestry-aware integration of tissue-specific genomic annotations enhances the transferability of polygenic scoresPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-11-13 · 1 citations

• CONCERT predicts niche-aware perturbation responses in spatial transcriptomicsPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-11-10 · 1 citations

• Melanoma to rhabdomyosarcoma plasticity in the setting of immunotherapyPreprint

  medRxiv · 2025-11-04

• Integrating single-cell RNA-seq datasets with substantial batch effects

  BMC Genomics · 2025-10-30 · 7 citations

• Programmed ribosomal frameshifting during <i>PLEKHM2</i> mRNA decoding generates a constitutively active proteoform that supports myocardial function

  Science Advances · 2025-10-24 · 3 citations

• Intraspecific sequence variation and complete genomes refine the identification of rapidly evolved regions in humansPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-10-21 · 3 citations

• Engineered 3D immuno-glial-neurovascular human miBrain model

  Proceedings of the National Academy of Sciences · 2025-10-17 · 12 citations

• Type 2 Diabetes and Obesity Alter Exercise Training-Induced Transcriptional Adaptations to Subcutaneous White Adipose TissuePreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-10-12

• Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer’s disease

  Molecular Neurodegeneration · 2025-10-01 · 10 citations