Manolis Kellis

Broad Institute

Full Professor(heuristic)

Genetic Associations and Epidemiology · Genetics

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h-index15
i10-index16
Publications22
Citations16,464

Grants

19 total · 5 active

NIH #R01NS127187

Identification of TDP-43 modifiers through single-cell transcriptional and epigenomic dissection of ALS and FTLD-MND

Expiring Soon
Amount
$2M–$3M
Period
2021-09-29 → 2026-08-31
PIs
4

Awarded at UNIVERSITY OF PITTSBURGH AT PITTSBURGH

NIH #R01DA063327

Integration and Validation of Single-Cell Neuronal and Immune Molecular Responses in SUD and HIV

Active
Amount
$500K–$600K
Period
2025-07-15 → 2030-03-31
PIs
2

Awarded at MASSACHUSETTS INSTITUTE OF TECHNOLOGY

NIH #R01AG081017

Single-cell multi-region dissection of AD-pathogen interactions for HSV-1 and CMV

Active
Amount
$700K–$800K
Period
2023-02-01 → 2028-01-31
PIs
2

Awarded at MASSACHUSETTS INSTITUTE OF TECHNOLOGY

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All Grants

19 total · 5 active

NIH #R01NS127187

Identification of TDP-43 modifiers through single-cell transcriptional and epigenomic dissection of ALS and FTLD-MND

Expiring Soon
Amount
$2M–$3M
Period
2021-09-29 → 2026-08-31
PIs
4

Awarded at UNIVERSITY OF PITTSBURGH AT PITTSBURGH

NIH #R01DA063327

Integration and Validation of Single-Cell Neuronal and Immune Molecular Responses in SUD and HIV

Active
Amount
$500K–$600K
Period
2025-07-15 → 2030-03-31
PIs
2

Awarded at MASSACHUSETTS INSTITUTE OF TECHNOLOGY

NIH #R01AG081017

Single-cell multi-region dissection of AD-pathogen interactions for HSV-1 and CMV

Active
Amount
$700K–$800K
Period
2023-02-01 → 2028-01-31
PIs
2

Awarded at MASSACHUSETTS INSTITUTE OF TECHNOLOGY

NIH #R01NS129032

Single-cell multi-region transcriptional and epigenomic dissection of VCID.

Active
Amount
$1M–$2M
Period
2022-09-15 → 2027-08-31
PIs
2

Awarded at MASSACHUSETTS INSTITUTE OF TECHNOLOGY

NIH #R01DA054584

Single-Cell Dissection of Ensembles and Cell Types Mediating Opioid Action in the Rodent Brain

Active
Amount
$600K–$700K
Period
2021-06-01 → 2027-02-28
PIs
3

Awarded at MASSACHUSETTS INSTITUTE OF TECHNOLOGY

NIH #U01DA053631

Single Cell Transcriptomic and Epigenomic Dissection of Opioid and Cocaine Responses in HIV

Amount
$2M–$3M
Period
2021-09-01 → 2026-06-30
PIs
2

Awarded at BROAD INSTITUTE, INC.

NIH #R01AG074003

Single-cell epigenomic and trancriptional dissection of sex-specific differences in Alzheimer’s Disease

Amount
$1M–$2M
Period
2021-09-30 → 2026-05-31
PIs
2

Awarded at MASSACHUSETTS INSTITUTE OF TECHNOLOGY

NIH #R01AG067151

Single-Cell Transcriptional and Epigenomic Dissection to Identify Therapeutic Targets for ALS and FTD

Amount
$700K–$800K
Period
2021-03-01 → 2025-11-30
PIs
2

Awarded at MASSACHUSETTS INSTITUTE OF TECHNOLOGY

NIH #RF1NS129032

Single-cell multi-region transcriptional and epigenomic dissection of VCID.

Amount
$3M–$4M
Period
2022-09-15 → 2025-08-31
PIs
2

Awarded at MASSACHUSETTS INSTITUTE OF TECHNOLOGY

NIH #R56AG081376

Investigating cell-type specific convergence of APOE and ABCA7 lipid dysregulation in Alzheimer’s disease

Amount
$700K–$800K
Period
2023-09-15 → 2024-08-31
PIs
2

Awarded at MASSACHUSETTS INSTITUTE OF TECHNOLOGY

NIH #UH3NS115064

Construction of an integrated immune - vascular brain - chip as a platform for the study, drug screening, and treatments of Alzheimer's disease

Amount
$1M–$2M
Period
2019-09-20 → 2024-05-31
PIs
3

Awarded at MASSACHUSETTS INSTITUTE OF TECHNOLOGY

NIH #R01AG062335

Elucidating the Molecular Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Disease

Amount
$1M–$2M
Period
2018-09-30 → 2023-05-31
PIs
2

Awarded at MASSACHUSETTS INSTITUTE OF TECHNOLOGY

NIH #U01NS110453

Single-cell transcriptional and epigenomic dissection of Alzheimer's Disease and Related Dementias

Amount
$1M–$2M
Period
2018-09-30 → 2022-08-31
PIs
2

Awarded at MASSACHUSETTS INSTITUTE OF TECHNOLOGY

NIH #R01AG058002

Epigenomic, transcriptional and cellular dissection of Alzheimer's variants

Amount
$1M–$2M
Period
2018-06-15 → 2022-05-31
PIs
4

Awarded at MASSACHUSETTS INSTITUTE OF TECHNOLOGY

NIH #UG3NS115064

Construction of an integrated immune - vascular brain - chip as a platform for the study, drug screening, and treatments of Alzheimer's disease

Amount
$2M–$3M
Period
2019-09-20 → 2021-05-31
PIs
3

Awarded at MASSACHUSETTS INSTITUTE OF TECHNOLOGY

NIH #R01MH109978

Network-based prediction and validation of causal schizophrenia genes and variants

Amount
$300K–$400K
Period
2018-03-01 → 2021-02-28
PIs
3

Awarded at MASSACHUSETTS INSTITUTE OF TECHNOLOGY

NIH #R56AG067151

Single-Cell Transcriptional and Epigenomic Dissection to Identify Therapeutic Targets for ALS and FTD

Amount
$700K–$800K
Period
2020-09-04 → 2021-02-28
PIs
1

Awarded at MASSACHUSETTS INSTITUTE OF TECHNOLOGY

NIH #U01MH119509

Single Cell Transcriptional and Epigenomic Dissection of Schizophrenia and Bipoloar Disease

Amount
$600K–$700K
Period
2019-06-01 → 2020-05-31
PIs
1

Awarded at MASSACHUSETTS INSTITUTE OF TECHNOLOGY

NSF #0644282

CAREER: Comparative Genomics and Biological Signal Discovery in the Human Genome

Amount
$1M–$2M
Period
2007-12-01 → 2014-11-30
PIs
1

Awarded at Massachusetts Institute of Technology

Recent Public Signals

  1. New paper: The hidden risk of round numbers and sharp thresholds in clinical practice (npj Digital Medicine)2025-11-21
  2. New preprint: A chromatin fiber model explains cell-free DNA fragmentation signatures of active regulatory elements2025-11-07
  3. New NIH award: Integration and Validation of Single-Cell Neuronal and Immune Molecular Responses in SUD and HIV2025-07-15

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Data Freshness

  • Publications as of 2026-07-09
  • Grants as of 2026-08-16

Data may not be current

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