Marcel Kool

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• Advancing CNS tumor diagnostics with expanded DNA methylation-based classification

  Cancer Cell · 2025-12-04 · 18 citations

• CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models

  Journal of Clinical Investigation · 2025-11-25 · 1 citations

• PTHP-09. High-resolution proteomic analysis of medulloblastoma clinical samples identifies MYC immunohistochemistry as a powerful outcome predictor outperforming genetic amplification detection

  Neuro-Oncology · 2025-11-01

• TMOD-24. Modeling Pediatric DMG in Human BrOs (Brainstem-regionalized Organoids) Dissects Tumour–Microglia–Immune Crosstalk and CAR T Cell Dysfunction

  Neuro-Oncology · 2025-11-01

• Inhibition of PARP results in highly effective radiosensitization of pediatric brain tumors without affecting normal tissue

  Klinische Pädiatrie · 2025-11-01

• P10.09.B SERPINB1 IMPROVES CLINICAL OUTCOME THROUGH INCREASING APOPTOSIS AND CHEMOSENSITIVITY IN MEDULLOBLASTOMA

  Neuro-Oncology · 2025-10-01

• P10.23.B UNCOVERING THERAPEUTIC VULNERABILITIES IN PEDIATRIC BCOR/L1-DRIVEN CNS TUMORS THROUGH MULTI-OMICS PROFILING

  Neuro-Oncology · 2025-10-01

• JS07.7.A VISTA IS A CRITICAL AND TARGETABLE IMMUNE CHECKPOINT PATHWAY IN DIFFUSE MIDLINE GLIOMA

  Neuro-Oncology · 2025-10-01

• P08.09.A COMBINED TARGETING OF TIGIT/LAG-3/PD-L1 IMMUNE CHECKPOINTS POTENTIATES NK CELL-MEDIATED CYTOTOXICITY IN MEDULLOBLASTOMA ORGANOIDS

  Neuro-Oncology · 2025-10-01

• Developing an advanced risk stratification model for pediatric intracranial ependymoma based on the prospective trial E-HIT2000 and subsequent registries

  Neuro-Oncology · 2025-09-11 · 1 citations

• Correction: Biglycan-driven risk stratification in ZFTA-RELA fusion supratentorial ependymomas through transcriptome profiling

  Acta Neuropathologica Communications · 2025-08-21

• A cycling, progenitor-like cell population at the base of atypical teratoid rhabdoid tumor subtype differentiation trajectories

  Neuro-Oncology · 2025-07-25 · 2 citations

• Advancing CNS tumor diagnostics with expanded DNA methylation-based classificationPreprint

  medRxiv · 2025-05-29 · 5 citations

• Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions

  Nature Cancer · 2025-05-26 · 5 citations

• Abstract 840: The ITCC-P4 consortium: Deep molecular characterization of pediatric cancer xenograft (PDX) models enable prediction of novel personalized combination treatment options for patients with childhood cancer

  Cancer Research · 2025-04-21

• Abstract 1202: Molecular profiles and drug response of ITCC-P4 patient-derived xenograft pediatric cancer models for target identification and prediction of targeted therapies

  Cancer Research · 2025-04-21

• Corrigendum to “Implementation of paediatric precision oncology into clinical practice: The individualized therapies for children with cancer program ‘iTHER’” [Eur J Cancer 175 (2022) 311–325]

  European Journal of Cancer · 2025-04-12 · 1 citations

• Abstract A013: Functional profiling in pediatric precision medicine: global collaboration to drive clinical implementation

  Cancer Research · 2025-03-11

• High-resolution proteomic analysis of medulloblastoma clinical samples identifies therapy-resistant subgroups and MYC immunohistochemistry as a powerful outcome predictor

  Neuro-Oncology · 2025-02-16 · 2 citations

• Abstract B028: Epigenetic landscape and gene regulations in embryonal brain tumors with multilayered rosettes (ETMR)

  Cancer Research · 2025-02-01