Melissa Cline

University of California, Santa Cruz

Full Professor(heuristic)

Genomics and Rare Diseases · Genetics

h-index46

i10-index60

Publications111

Citations20,654

Grants

5 total · 1 active

NIH #1U24CA302705-01

The BRCA Exchange Knowledgebase for Clinical Cancer Genetics

Active

Amount: $660K
Period: 2025-09-01 → 2030-08-31
PIs: 1
Est. capacity / PI: ~9 students

Awarded at UNIVERSITY OF CALIFORNIA SANTA CRUZ

NIH #5U01CA242954-03

Eliminating variants of uncertain significance in BRCA1, BRCA2 and beyond

Amount: $595K
Period: 2019-09-01 → 2023-08-31
PIs: 1
Est. capacity / PI: ~0 students

Awarded at UNIVERSITY OF CALIFORNIA SANTA CRUZ

NIH #3U01CA242954-02S1

Federated Analysis in Cancer Genomics: Surveying the Social, Ethical, and Regulatory Landscape

Amount: $131K
Period: 2019-09-01 → 2022-08-31
PIs: 1
Est. capacity / PI: ~0 students

Awarded at UNIVERSITY OF CALIFORNIA SANTA CRUZ

Student capacity is a rough estimate from remaining award size, split equally among PIs. Actual funding decisions vary.

Lab Funding Health

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In-Field Influence

0.0007

PageRank within Genetics co-authorship network

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Admission Signals

New NIH award: $660K — The BRCA Exchange Knowledgebase for Clinical Cancer Genetics2025-09-01
New paper: When two plus four does not equal six: Combining computational and functional evidence to classify BRCA1 key domain missense substitutions (The American Journal of Human Genetics)2025-08-18
New preprint: When Two plus Four Does Not Equal Six: Combining Computational and Functional Evidence to Classify BRCA1 Key Domain Missense Substitutions.2024-10-10

Data Freshness

Publications as of 2026-07-01
Grants as of 2026-06-30

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ORCID: 0000-0002-0148-1956

Career Trajectory

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Recent Publications

Last 2 years · showing 7 of 7

When two plus four does not equal six: Combining computational and functional evidence to classify BRCA1 key domain missense substitutions
The American Journal of Human Genetics · 2025-08-18 · 1 citations
Mapping MAVE data for use in human genomics applications
Genome biology · 2025-06-25 · 11 citations
P411: An atypical presentation of Werner syndrome in a patient with a novel likely pathogenic variant in WRN: A case report
Genetics in Medicine Open · 2025-01-01
When Two plus Four Does Not Equal Six: Combining Computational and Functional Evidence to Classify BRCA1 Key Domain Missense Substitutions.Preprint
medRxiv · 2024-10-10 · 1 citations
Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline ATM sequence variants
The American Journal of Human Genetics · 2024-09-23 · 17 citations
Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classificationPreprint
medRxiv · 2024-09-04 · 3 citations
Evidence-based recommendations for gene-specific ACMG/AMP variant classification from the ClinGen ENIGMA BRCA1 and BRCA2 Variant Curation Expert Panel
The American Journal of Human Genetics · 2024-08-13 · 90 citations

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