Paul S. Mischel

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• ERO1a fosters glioblastoma aggressiveness and metabolic flexibility by regulating mitochondria-associated membrane dynamics

  Nature Cell Biology · 2026-06-12

• Accurate prediction of ecDNA in interphase cancer cells using deep neural networks

  Communications Biology · 2026-04-11

• Abstract 66: Gene co-amplification and structural patterns reveal principles of extrachromosomal DNA in cancer.

  Cancer Research · 2026-04-03

• Abstract 4689: Dynamic and defective repair of extrachromosomal DNA drives genome instability in cancer

  Cancer Research · 2026-04-03

• Abstract 1930: Unveiling ecDNA spatial organization and epigenetic landscapes through long-read multi-omic sequencing and high-content microscopy.

  Cancer Research · 2026-04-03

• Abstract 4065: EcDNA-borne structural variants drive oncogenic fusion transcript amplification

  Cancer Research · 2026-04-03

• Abstract 1925: De novo enhancer formation at human-viral junctions drives hybrid extrachromosomal DNA amplification in HPV-associated cancer.

  Cancer Research · 2026-04-03

• A recipe for chaos: Extrachromosomal DNA and the hallmarks of cancer

  Cell · 2026-04-01 · 2 citations

• Dynamic optimization of extrachromosomal DNA copy number drives tumour evolution

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-03-23

• Fast and accurate resolution of ecDNA sequence using Cycle-Extractor

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-03-13

• Abstract A007: EcDNA-derived structural variants: A common pathway to oncogenic fusion transcript amplification in cancer

  Cancer Research · 2026-01-13

• EcDNA-borne structural variants drive oncogenic fusion transcript amplification

  Cell · 2026-01-07 · 4 citations

• Innate immune sensing via the cGAS-STING pathway restricts extrachromosomal DNA–driven tumorigenesis

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-01-01 · 1 citations

• Reconstructing the three-dimensional architecture of extrachromosomal DNA with ec3D

  Nature Communications · 2025-12-20 · 1 citations

• Applications of transcranial focused ultrasound for primary brain tumors

  Neuro-Oncology Advances · 2025-12-02

• Genetic elements promote retention of extrachromosomal DNA in cancer cells

  Nature · 2025-11-19 · 11 citations

• Enhancer activation from transposable elements in extrachromosomal DNA

  Nature Cell Biology · 2025-10-21 · 12 citations

• Genetic elements promote retention of extrachromosomal DNA in cancer cellsPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-10-12 · 1 citations

• Figure 2 from Extrachromosomal DNA–Driven Oncogene Spatial Heterogeneity and Evolution in Glioblastoma

  2025-10-06

• Supplementary Figures from Extrachromosomal DNA–Driven Oncogene Spatial Heterogeneity and Evolution in Glioblastoma

  2025-10-06