Rudolph E. Tanzi

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• Machine Learning-Enhanced Hyperspectral Raman Imaging for Label-Free Molecular Atlas of Alzheimer’s Brain

  ACS Applied Materials & Interfaces · 2025-12-31

• Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons

  Nature Neuroscience · 2025-12-17 · 10 citations

• Effects of nicotinamide riboside on NAD+ levels, cognition, and symptom recovery in long-COVID: a randomized controlled trial

  EClinicalMedicine · 2025-11-01 · 3 citations

• The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function

  Neuron · 2025-10-17 · 5 citations

• Increase of brain Aβ peptides and secretase activity during normal aging in rodent and human

  GeroScience · 2025-10-14 · 1 citations

• Efficacy of AD04, an aluminum-based vaccine adjuvant, in patients with early Alzheimer's disease: Post hoc analysis of AFF006 (NCT01117818), a proof-of-concept, phase 2 randomized controlled trial

  Journal of Alzheimer s Disease · 2025-09-15 · 3 citations

• Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer’s disease

  Science Translational Medicine · 2025-07-30 · 4 citations

• Human amylin is a potent antimicrobial peptide that exhibits antimicrobial synergism with the amyloid beta protein

  Alzheimer s & Dementia · 2025-07-29 · 3 citations

• Context-dependent regulatory variants in Alzheimer’s diseasePreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-07-11 · 3 citations

• SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids

  Science Advances · 2025-07-04 · 10 citations

• A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer’s disease

  Science Signaling · 2025-07-01 · 2 citations

• Evasion of complement and amyloid-beta by the neurotropic pathogen Borrelia burgdorferi in human 3D cultures

  Immunobiology · 2025-07-01 · 1 citations

• Inhibition of Acyl-CoA: Cholesterol Acyltransferase 1 Promotes Shedding of Soluble TREM2 and LRP1-Dependent Phagocytosis of Amyloid β Protein in MicrogliaPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-06-15

• Linking sleep microstructure, blood markers of inflammation and metabolism, and cognition: mediation analysis in the osteoporotic fractures in men study

  GeroScience · 2025-06-14 · 2 citations

• Uncovering Ethnicity‐Specific Recessive Loci for Alzheimer's Disease in 89 Dominican Families Using Family‐Based WGS Analysis

  Genetic Epidemiology · 2025-06-09

• The Brain Care Score and its associations with cardiovascular disease and cancer

  Family Practice · 2025-06-04 · 1 citations

• Acute experimental colitis in 5xFAD Alzheimer's disease mice leads to enhanced monocyte infiltration into the brain accompanied by reduced β‐amyloid deposition

  Alzheimer s & Dementia · 2025-06-01 · 3 citations

• Use of the Brain Care Score to Estimate the Risk of Incident Cerebrovascular Events in Middle-Aged Women

  Neurology · 2025-05-16 · 4 citations

• Protein kinase C eta enhances Golgi-localized signaling and is associated with Alzheimer’s disease using a recessive mode of inheritancePreprint

  medRxiv · 2025-05-14 · 1 citations

• Associations of APOE variants with sphingomyelin and cholesterol metabolites across the life-course in diverse populations

  Metabolomics · 2025-05-07 · 1 citations