Scot A. Wolfe

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• Fully Modified SpyCas9 Guide RNAs Enable Robust Genome Editing In Cells and In Vivo

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-05-28

• Systemic delivery of CRISPR-Cas9 nickase suppresses oncogene amplified cancer progression

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-04-27

• Adissp activates insulin-independent glucose disposal and energy expenditure in white fat to treat diabetes and cardiometabolic disease

  Science Advances · 2026-04-24

• SORT LNPs encapsulating Cas9 mRNA achieve efficient editing in skeletal muscle in a dystrophic mouse model

  Molecular Therapy · 2026-03-01

• Testing a dual AAV gene therapy vector construct to treat sialidosis and galactosialidosis using small and large animal models

  Molecular Genetics and Metabolism · 2026-02-01

• Modular Platform for Therapeutic Drug Delivery Using Trifunctional Bio-Orthogonal Macromolecular Conjugates

  Bioconjugate Chemistry · 2025-11-10 · 1 citations

• Efficient prime editing of human hematopoietic stem cells corrects the recurrent SBDS C.258+2T>C mutation and recovers engraftment potential in shwachman-diamond syndrome

  Blood · 2025-11-03 · 1 citations

• Efficient, potent, and specific near-universal base and prime editing for ELANE-mutant severe congenital neutropenia

  Blood · 2025-11-03

• Reassessment of Biomarkers and Acceptance Criteria in Normothermic Machine Perfusion for Liver Allografts

  American Journal of Transplantation · 2025-08-01 · 1 citations

• Evaluating the Impact of Normothermic Machine Perfusion on Liver Transplant Outcomes and Surgical Team Wellbeing

  American Journal of Transplantation · 2025-08-01

• Modular platform for therapeutic drug delivery using trifunctional bio-orthogonal macromolecular conjugatesPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-07-26

• Selective targeting of genome amplifications and repeat elements by CRISPR-Cas9 nickases to promote cancer cell death

  Nature Communications · 2025-06-02 · 7 citations

• Identifying optimal conditions for precise knock-in of exogenous DNA into the zebrafish genome

  Development · 2025-05-30 · 4 citations

• Efficient Cas9 nuclease-based editing in skeletal muscle via lipid nanoparticle deliveryPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-05-12 · 3 citations

• Direct delivery of Cas-embedded cytosine base editors as ribonucleoprotein complexes for efficient and accurate editing of clinically relevant targets

  Nucleic Acids Research · 2024-12-16 · 5 citations

• Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells

  Cell stem cell · 2024-12-12 · 23 citations

• BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate

  Cell stem cell · 2024-12-05 · 16 citations

• The co-receptor Neuropilin-1 enhances proliferation in inv(16) acute myeloid leukemia via VEGF signaling

  Leukemia · 2024-11-21 · 8 citations

• Increasing intracellular dNTP levels improves prime editing efficiency

  Nature Biotechnology · 2024-09-25 · 26 citations

• Scalable assessment of genome editing off-targets associated with genetic variantsPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2024-07-25 · 2 citations