Steven E. Brenner

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• predNMD: prediction of nonsense-mediated mRNA decay for improved clinical variant pathogenicity classification

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-06-23

• Nominating Genetically Driven Immune Disease Genes for BEACONS: The First U.S. Multistate Genomic Newborn Screening Initiative

  Journal of Human Immunity · 2026-05-01

• Advances in Protein Function Prediction from the Fifth CAFA Challenge

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-04-30 · 1 citations

• Calibration of in-frame indel variant effect predictors for clinical variant classification

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-04-18

• Improving variant classification through data aggregation and calibration

  Pathology · 2026-02-01

• Trust, Reproducibility, and Progress: The Roles of Independent Blind Prediction and Assessment and Benchmarking in Computational Biology

  2025-12-01

• Session Introduction: Precision Medicine: Integrating Large-Scale Data and Intermediate Phenotypes for Understanding Health and Treating Disease

  2025-12-01

• Evaluation of enzyme activity predictions for variants of unknown significance in Arylsulfatase A

  UNC Libraries · 2025-03-20

• Calibration of additional computational tools expands ClinGen recommendation options for variant classification with PP3/BP4 criteria

  Genetics in Medicine · 2025-03-10 · 45 citations

• Evaluation of enzyme activity predictions for variants of unknown significance in Arylsulfatase A

  Human Genetics · 2025-03-01 · 1 citations

• Critical assessment of missense variant effect predictors on disease-relevant variant data

  Human Genetics · 2025-03-01 · 21 citations

• Assessing the predicted impact of single amino acid substitutions in MAPK proteins for CAGI6 challenges

  Human Genetics · 2025-02-20

• Disruption of the moonlighting function of CTF18 in a patient with T-lymphopenia

  Frontiers in Immunology · 2025-02-14

• Evaluating predictors of kinase activity of STK11 variants identified in primary human non-small cell lung cancers

  Human Genetics · 2025-02-11 · 1 citations

• Assessing the predicted impact of single amino acid substitutions in calmodulin for CAGI6 challenges

  Human Genetics · 2024-12-23

• Session Introduction: Precision Medicine: Multi-modal and multi-scale methods to promote mechanistic understanding of disease

  2024-11-21

• Calibration of additional computational tools expands ClinGen recommendation options for variant classification with PP3/BP4 criteriaPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2024-09-21 · 13 citations

• Variant Impact Predictor database (VIPdb), version 2: trends from three decades of genetic variant impact predictors

  Human Genomics · 2024-08-28 · 13 citations

• Assessing predictions on fitness effects of missense variants in HMBS in CAGI6

  Human Genetics · 2024-08-07 · 2 citations

• Assessment of the evidence yield for the calibrated PP3/BP4 computational recommendations

  Genetics in Medicine · 2024-07-24 · 16 citations