Stuart H. Orkin

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• Silencing of BCL11A by disrupting enhancer-dependent epigenetic insulation

  Blood · 2025-11-05 · 2 citations

• Silencing of BCL11A by disrupting enhancer-dependent epigenetic insulation

  Blood · 2025-11-03

• The Fetal-to-Adult Hemoglobin Switch — Mechanism and Therapy

  New England Journal of Medicine · 2025-06-04 · 9 citations

• RNA Editors Sculpt the Transcriptome During Terminal ErythropoiesisPreprint

  Research Square · 2025-04-24

• RNA Editors Sculpt the Transcriptome During Terminal ErythropoiesisPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-04-05

• Redirecting E3 ubiquitin ligases for targeted protein degradation with heterologous recognition domains

  Journal of Biological Chemistry · 2024-12-13 · 10 citations

• Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells

  Cell stem cell · 2024-12-12 · 23 citations

• A tetramer of BCL11A is required for stable protein production and fetal hemoglobin silencing

  Science · 2024-11-28 · 16 citations

• Structural insights into the DNA-binding mechanism of BCL11A: The integral role of ZnF6

  Structure · 2024-10-17 · 6 citations

• The epigenetic state of the cell of origin defines mechanisms of leukemogenesis

  Leukemia · 2024-10-01 · 3 citations

• 3149 – THE EPIGENETIC STATE OF THE CELL OF ORIGIN DEFINES MECHANISMS OF LEUKEMOGENESIS

  Experimental Hematology · 2024-08-01