Thea D. Tlsty

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor MicroenvironmentPreprint

  eLife · 2025-10-17 · 1 citations

• Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor MicroenvironmentPreprint

  eLife · 2025-10-17

• Concerted changes in Epithelium and Stroma: a multi-scale, multi-omics analysis of progression from Barrett’s Esophagus to adenocarcinoma

  Developmental Cell · 2025-07-21 · 8 citations

• A Fibroblast State Choreographs an Epithelial YAP-dependent Regenerative Program Essential to (Pre)malignancy via ECM-mediated MechanotransductionPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-07-11 · 1 citations

• Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor MicroenvironmentPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-07-07

• Alterations of the composition and spatial organization of the microenvironment following non-dysplastic Barrett’s esophagus through progression to cancerPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-06-12 · 3 citations

• The Promise study: A presurgical randomized clinical trial of CE/BZA vs placebo in postmenopausal women with ductal carcinoma in situ.

  Journal of Clinical Oncology · 2025-05-28

• Paired mutation calling and spatial transcriptomics identify cellular neighbourhoods dictating the neoplastic outcome of colitisPreprint

  Research Square · 2025-05-08

• Proteomic Analysis of Breast Cancer Subtypes Identifies Stromal Protein Profiles that Contribute to Aggressive Malignant BehaviorPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-01-24

• A hybrid epithelial-mesenchymal transition program enables basal epithelial cells to bypass stress-induced stasis and contributes to a metaplastic breast cancer progenitor state

  Breast Cancer Research · 2024-12-18 · 6 citations

• Defining precancer: a grand challenge for the cancer community

  Nature reviews. Cancer · 2024-10-01 · 32 citations

• An adaptive Epithelial-Mesenchymal Transition Program Enables Basal Epithelial Cells to Bypass Stress-Induced Stasis and Contributes to Metaplastic Breast Cancer Progenitor StatePreprint

  Research Square · 2024-09-27

• Higher Nodal expression is often associated with poorer survival in patients diagnosed with melanoma and treated with anti-PD1 therapy

  Pathology & Oncology Research · 2024-09-23