Timothy R. Hughes

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

• Inferring binding specificities of human transcription factors with the wisdom of crowdsPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-11-17 · 2 citations

• Cross-platform motif discovery and benchmarking to explore binding specificities of poorly studied human transcription factors

  Communications Biology · 2025-11-07 · 5 citations

• Frontline tyrosine kinase inhibitor selection influences eventual treatment-free remission eligibility and sustained treatment-free remission: A registry analysis of patients treated at CML referral sites in Australia

  Blood · 2025-11-03

• High dose ascorbate downregulates innate immune cytokines in the bone marrow of TET2 mutant chronic myelomonocytic leukemia

  Blood · 2025-11-03

• Unravelling the epigenetic drivers of chip – MDS/CMML – AML progression through novel methylation-sensitive regulatory elements

  Blood · 2025-11-03

• Numerous clinically-detected asciminib-resistant BCR::ABL1 mutations disrupt allostery and confer cross-resistance to the novel clinically-active allosteric TKI tgrx-678

  Blood · 2025-11-03

• Whole genome sequencing reveals that the Philadelphia chromosome (Ph) can evolve and gain complex chromoplectic sequence rearrangements associated with tyrosine kinase inhibitor (TKI) resistance

  Blood · 2025-11-03

• Differential usage of two, distinct DNA-binding domains regulates tissue-specific occupancy of the pioneer factor ZeldaPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-10-07

• CisBP-RNA: a web resource for eukaryotic RNA-binding proteins and their motifs

  Nucleic Acids Research · 2025-10-04 · 11 citations

• A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function

  Nature Biotechnology · 2025-07-25 · 12 citations

• Durable Responses to Lenzilumab: Azacitidine Combination Therapy in High Risk Proliferative Chronic Myelomonocytic Leukaemia with Suppression of CBL and RAS Mutant Subclones

  EMJ Hematology · 2025-07-24

• Systematic investigation reveals extensive Epstein-Barr virus transcriptional regulation of the human genomePreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2025-07-20 · 3 citations

• Multi-species analysis of inflammatory response elements reveals ancient and lineage-specific contributions of transposable elements to NF-kB binding

  Genome Research · 2025-06-06 · 3 citations

• At‐ <scp>RS31</scp> orchestrates hierarchical cross‐regulation of splicing factors and integrates alternative splicing with <scp>TOR</scp> ‐ <scp>ABA</scp> pathways

  New Phytologist · 2025-05-26 · 14 citations

• A TATA-box-binding protein binds single-stranded DNA in two modes: To poly(G) tracts and to flexible DNA regions

  Journal of Biological Chemistry · 2025-04-27

• A multimorphic variant in ThPOK causes an inborn error of immunity with T cell defects and fibrosis

  The Journal of Experimental Medicine · 2025-03-29 · 1 citations

• At-RS31 orchestrates hierarchical cross-regulation of splicing factors and integrates alternative splicing with TOR-ABA pathwaysPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2024-12-07 · 1 citations

• Extensive binding of nebulous human transcription factors to genomic dark matterPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2024-11-12 · 10 citations

• Cross-platform DNA motif discovery and benchmarking to explore binding specificities of poorly studied human transcription factorsPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2024-11-12 · 1 citations

• Identification of methylation-sensitive human transcription factors using meSMiLE-seqPreprint

  bioRxiv (Cold Spring Harbor Laboratory) · 2024-11-12 · 5 citations