Yong Cheng

St. Jude Children's Research Hospital

Full Professor(heuristic)

Genomics and Chromatin Dynamics · Molecular Biology

h-index41

i10-index55

Publications128

Citations19,087

Grants

16 total · 7 active

NIH #1R01AI187465-01A1

Epigenetic Checkpoint Regulation of Naive T-cell Quiescence and Peripheral Tolerance

Active

Amount: $3.4M
Period: 2025-07-22 → 2029-06-30
PIs: 2
Est. capacity / PI: ~21 students

NIH #5R01HG013981-02

Deciphering the underlying structure of the glucocorticoid gene regulatory network

Active

Amount: $817K
Period: 2025-04-01 → 2029-03-31
PIs: 2
Est. capacity / PI: ~4 students

NIH #1R01HG013981-01

Deciphering the underlying structure of the glucocorticoid gene regulatory network

Active

Amount: $814K
Period: 2025-04-01 → 2029-03-31
PIs: 2
Est. capacity / PI: ~4 students

Student capacity is a rough estimate from remaining award size, split equally among PIs. Actual funding decisions vary.

Lab Funding Health

Find elsewhere

Institution / lab homepage Search on ResearchGate

In-Field Influence

0.0002

PageRank within Molecular Biology co-authorship network

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Admission Signals

New paper: Single-cell transcriptomics reveals heterocellular γ-globin gene expression in Aγδβ-thalassemia (Blood Advances)2025-12-06
New preprint: The H3K4 methyltransferase KMT2D is an essential cofactor for GATA1 at erythroid gene enhancers2025-10-22
New NSF award: $200K — Collaborative Research: Quantum Algorithms for High-Performance Analysis of Single-Cell Omics Data and Explainable Drug Discovery2025-09-01
New NIH award: $3,428K — Epigenetic Checkpoint Regulation of Naive T-cell Quiescence and Peripheral Tolerance2025-07-22
New NIH award: $817K — Deciphering the underlying structure of the glucocorticoid gene regulatory network2025-04-01
New NIH award: $814K — Deciphering the underlying structure of the glucocorticoid gene regulatory network2025-04-01
New NIH award: $1,192K — The role of FENDRR in host defense against Mycobacterium tuberculosis infection2022-09-21
New NIH award: $596K — The role of FENDRR in host defense against Mycobacterium tuberculosis infection2022-09-21
New NIH award: $579K — The role of FENDRR in host defense against Mycobacterium tuberculosis infection2022-09-21

Data Freshness

Publications as of 2026-07-01
Grants as of 2026-06-30

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ORCID: 0000-0002-9314-0971

Career Trajectory

Research Cluster Map

Direct collaborators. Node size = influence, colour = community, dashed = past collaboration.

Potential Collaborators

Recent Publications

Last 2 years · showing 20 of 20

Single-cell transcriptomics reveals heterocellular γ-globin gene expression in Aγδβ-thalassemia
Blood Advances · 2025-12-06 · 2 citations
Silencing of BCL11A by disrupting enhancer-dependent epigenetic insulation
Blood · 2025-11-05 · 2 citations
Silencing of BCL11A by disrupting enhancer-dependent epigenetic insulation
Blood · 2025-11-03
Machine learning replicates and extends clinician-informed disease severity grading classification for acute pain and CKD in sickle cell disease
Blood · 2025-11-03
Single-cell analysis reveals distinct γ-globin expression profiles in sickle cell disease with pancellular fetal hemoglobin
Blood · 2025-11-03
The correlation of DPM1 overexpression with immune infiltration and poor prognosis in hepatocellular carcinoma
Discover Oncology · 2025-10-27
The H3K4 methyltransferase KMT2D is an essential cofactor for GATA1 at erythroid gene enhancersPreprint
Research Square · 2025-10-22
Enhancing lipase activity in Aspergillus niger through CRISPR/Cas9-mediated protease gene knockout and fermentation optimization
Biotechnology Letters · 2025-09-25
Murine hematopoietic progenitor cell lines with erythroid and megakaryocyte potential
Nature Communications · 2025-08-07 · 1 citations
Removal of promoter CpG methylation by epigenome editing reverses HBG silencing
Nature Communications · 2025-07-27 · 8 citations
BCL11A-deficient human erythropoiesis is impaired in vitro and after xenotransplantation into mice
Blood Advances · 2025-02-28 · 14 citations
Population-scale cellular GUIDE-seq-2 and biochemical CHANGE-seq-R profiles reveal human genetic variation frequently affects Cas9 off-target activityPreprint
bioRxiv (Cold Spring Harbor Laboratory) · 2025-02-12 · 13 citations
Preclinical development of lentiviral vector gene therapy for Diamond-Blackfan anemia syndrome
Molecular Therapy · 2024-12-12 · 4 citations
SAGES1: Clinical Translation of CRISPR Genome Editing Strategy to Induce Fetal Hemoglobin to Treat Sickle Cell Disease
Blood · 2024-11-05 · 4 citations
An Essential Role for the N-Terminus of GATA1 in Metabolic Regulation during Erythropoiesis
Blood · 2024-11-05
Towards Democratization of Subspeciality Medical ExpertisePreprint
arXiv (Cornell University) · 2024-10-01 · 3 citations
Transcription factor 4 is a key mediator of oncogenesis in neuroblastoma by promoting <scp>MYC</scp> activity
Molecular Oncology · 2024-08-09 · 3 citations
Development and IND-enabling studies of a novel Cas9 genome-edited autologous CD34+ cell therapy to induce fetal hemoglobin for sickle cell disease
Molecular Therapy · 2024-07-30 · 15 citations
[Effect of obstructive sleep apnea on the severity of acute coronary syndrome].
PubMed · 2024-07-16
[Correlation between arousal threshold and occurrence of hypertension in patients with obstructive sleep apnea hypopnea syndrome].
PubMed · 2024-07-12

Open author page on OpenAlex →

Yong Cheng

Grants

Epigenetic Checkpoint Regulation of Naive T-cell Quiescence and Peripheral Tolerance

Deciphering the underlying structure of the glucocorticoid gene regulatory network

Deciphering the underlying structure of the glucocorticoid gene regulatory network

All Grants

Epigenetic Checkpoint Regulation of Naive T-cell Quiescence and Peripheral Tolerance

Deciphering the underlying structure of the glucocorticoid gene regulatory network

Deciphering the underlying structure of the glucocorticoid gene regulatory network

Collaborative Research: Quantum Algorithms for High-Performance Analysis of Single-Cell Omics Data and Explainable Drug Discovery

The role of FENDRR in host defense against Mycobacterium tuberculosis infection

The role of FENDRR in host defense against Mycobacterium tuberculosis infection

The role of FENDRR in host defense against Mycobacterium tuberculosis infection

Identification of causal non-coding variants in childhood genetic disorders

The role of FENDRR in host defense against Mycobacterium tuberculosis infection

Genome-wide screening for host lncRNAs regulating host defense against Mycobacterial infection in macrophages

Identification of causal non-coding variants in childhood genetic disorders

Identification of causal non-coding variants in childhood genetic disorders

Identification of causal non-coding variants in childhood genetic disorders

Identification of causal non-coding variants in childhood genetic disorders

Project 5: Understanding the Mechanism of Immune Dysfunction in a Cystic Fibrosis Murine Model During Nontuberculous Mycobacterial Infection

Genome-wide screening for host lncRNAs regulating host defense against Mycobacterial infection in macrophages

Career Trajectory

Research Cluster Map

Potential Collaborators

Recent Publications